Clustal is a widely used, multiple sequence alignment program. This is Clustal Omega, the latest addition to the Clustal family. It offers a significant increase in scalability over previous versions, allowing hundreds of thousands of sequences to be aligned in only a few hours. In addition, the quality of alignments is superior to previous versions, as measured by a range of popular benchmarks. Clustal Omega is currently a command line-only tool, and is only suitable for aligning protein sequences, not DNA or RNA. This requires argtable.